Journal article

The Natural History of Anal High-grade Squamous Intraepithelial Lesions in Gay and Bisexual Men

I Mary Poynten, Fengyi Jin, Jennifer M Roberts, David J Templeton, Carmella Law, Alyssa M Cornall, Monica Molano, Dorothy A Machalek, Andrew Carr, Annabelle Farnsworth, Sepehr Tabrizi, Samuel Phillips, Christopher K Fairley, Suzanne M Garland, Richard J Hillman, Andrew E Grulich

CLINICAL INFECTIOUS DISEASES | OXFORD UNIV PRESS INC | Published : 2021

Abstract

BACKGROUND: Gay and bisexual men (GBM) are disproportionately affected by anal cancer. Prevention is hindered by incomplete understanding of the natural history of its precursor, anal high-grade squamous intraepithelial lesions (HSIL). METHODS: The Study of the Prevention of Anal Cancer, conducted between 2010 and 2018, enrolled human immunodeficiency virus (HIV)-positive and HIV-negative GBM aged ≥35 years. Anal cytology and high-resolution anoscopy (HRA) were performed at baseline and 3 annual visits. A composite HSIL diagnosis (cytology ± histology) was used. Cytological high-grade squamous intraepithelial lesions (cHSIL) incidence and clearance rates were calculated with 95% confidence i..

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Grants

Awarded by National Health and Medical Research Council Program Grant (Sexually Transmitted Infections: causes, consequences and interventions grant)


Awarded by Cancer Council New South Wales Strategic Research Partnership Program Grant (Preventing morbidity and mortality from anal cancer grant)


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council Program Grant (Sexually Transmitted Infections: causes, consequences and interventions grant 568971); and a Cancer Council New South Wales Strategic Research Partnership Program Grant (Preventing morbidity and mortality from anal cancer grant 13-11). Cytological testing materials were provided by Hologic (Australia) Pty Ltd. The Kirby Institute is affiliated with the Faculty of Medicine, University of New South Wales, and funded by the Australian Government of Health and Ageing.