Journal article

The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability

Scott Peng, Megan S Grace, Arisbel B Gondin, Jeffri S Retamal, Larissa Dill, William Darby, Nigel W Bunnett, Fe C Abogadie, Simona E Carbone, Tara Tigani, Thomas P Davis, Daniel P Poole, Nicholas A Veldhuis, Peter McIntyre

Laboratory Investigation | NATURE PUBLISHING GROUP | Published : 2020

Abstract

Endothelial barrier disruption is a hallmark of tissue injury, edema, and inflammation. Vascular endothelial cells express the G protein-coupled receptor (GPCR) protease acctivated receptor 1 (PAR1) and the ion channel transient receptor potential vanilloid 4 (TRPV4), and these signaling proteins are known to respond to inflammatory conditions and promote edema through remodeling of cell-cell junctions and modulation of endothelial barriers. It has previously been established that signaling initiated by the related protease activated receptor 2 (PAR2) is enhanced by TRPV4 in sensory neurons and that this functional interaction plays a critical role in the development of neurogenic inflammati..

View full abstract

University of Melbourne Researchers

Grants

Awarded by NHMRC Australia


Funding Acknowledgements

Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (NWB, TPD), NHMRC Australia 1046860 (PM, NWB), 1083480 (DPP).