The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability
Scott Peng, Megan S Grace, Arisbel B Gondin, Jeffri S Retamal, Larissa Dill, William Darby, Nigel W Bunnett, Fe C Abogadie, Simona E Carbone, Tara Tigani, Thomas P Davis, Daniel P Poole, Nicholas A Veldhuis, Peter McIntyre
LABORATORY INVESTIGATION | NATURE PUBLISHING GROUP | Published : 2020
Endothelial barrier disruption is a hallmark of tissue injury, edema, and inflammation. Vascular endothelial cells express the G protein-coupled receptor (GPCR) protease acctivated receptor 1 (PAR1) and the ion channel transient receptor potential vanilloid 4 (TRPV4), and these signaling proteins are known to respond to inflammatory conditions and promote edema through remodeling of cell-cell junctions and modulation of endothelial barriers. It has previously been established that signaling initiated by the related protease activated receptor 2 (PAR2) is enhanced by TRPV4 in sensory neurons and that this functional interaction plays a critical role in the development of neurogenic inflammati..View full abstract
Awarded by NHMRC Australia
Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (NWB, TPD), NHMRC Australia 1046860 (PM, NWB), 1083480 (DPP).