Ocular biomarkers for cognitive impairment in nonagenarians; a prospective cross-sectional study
Jacoba A van de Kreeke, Nienke Legdeur, Maryam Badissi, H Ton Nguyen, Elles Konijnenberg, Jori Tomassen, Mara ten Kate, Anouk den Braber, Andrea B Maier, H Stevie Tan, Frank D Verbraak, Pieter Jelle Visser
BMC Geriatrics | BMC | Published : 2020
BACKGROUND: Ocular imaging receives much attention as a source of potential biomarkers for dementia. In the present study, we analyze these ocular biomarkers in cognitively impaired and healthy participants in a population aged over 90 years (= nonagenarian), and elucidate the effects of age on these biomarkers. METHODS: For this prospective cross-sectional study, we included individuals from the EMIF-AD 90+ study, consisting of a cognitively healthy (N = 67) and cognitively impaired group (N = 33), and the EMIF-AD PreclinAD study, consisting of cognitively healthy controls aged ≥60 (N = 198). Participants underwent Optical Coherence Tomography (OCT) and fundus photography of both eyes. OCT ..View full abstract
Awarded by EU/EFPIA Innovative Medicines Initiative Joint Undertaking (EMIF)
This work has received support from the EU/EFPIA Innovative Medicines Initiative Joint Undertaking (EMIF grant number 115372).