Altered Caecal Neuroimmune Interactions in the Neuroligin-3R451C Mouse Model of Autism

SS Sharna; GK Balasuriya; S Hosie; J Nithianantharajah; AE Franks; EL Hill-Yardin

Journal article

Altered Caecal Neuroimmune Interactions in the Neuroligin-3R451C Mouse Model of Autism

SS Sharna, GK Balasuriya, S Hosie, J Nithianantharajah, AE Franks, EL Hill-Yardin

Frontiers in Cellular Neuroscience | FRONTIERS MEDIA SA | Published : 2020

DOI: 10.3389/fncel.2020.00085

Download PDF

Abstract

The intrinsic nervous system of the gut interacts with the gut-associated lymphoid tissue (GALT) via bidirectional neuroimmune interactions. The caecum is an understudied region of the gastrointestinal (GI) tract that houses a large supply of microbes and is involved in generating immune responses. The caecal patch is a lymphoid aggregate located within the caecum that regulates microbial content and immune responses. People with Autism Spectrum Disorder (ASD; autism) experience serious GI dysfunction, including inflammatory disorders, more frequently than the general population. Autism is a highly prevalent neurodevelopmental disorder defined by the presence of repetitive behavior or restri..

View full abstract

University of Melbourne Researchers

Suzanne Hosie Author

Jess Nithianantharajah Author

Elisa Hill Author

Related Projects (2)

UNDERSTANDING THE BASIS OF COMPLEX BEHAVIOUR

This project is anchored in the fundamental understanding of complex vertebrate behaviours, namely cognition. Little is known about the mole..

DISSECTING THE ROLE OF NEUROLIGINS IN COGNITION

Problems in learning, memory and other complex mental processes are common to many brain disorders. This project will study the impact of mu..

Grants

Awarded by Mayo Clinic

Funding Acknowledgements

This work was supported by the Australian Research Council Future Fellowship (FT160100126) to EH-Y and National Health and Medical Research Council Project Grant (APP1083334) and Australian Research Council Future Fellowship (FT140101327) to JN. EH-Y also received an RMIT Vice Chancellor's Senior Research Fellowship, which supported GB and SH. The Hu antibody was a gift from Dr. V. Lennon, Mayo Clinic, USA.