Journal article
Altered Caecal Neuroimmune Interactions in the Neuroligin-3(R451C) Mouse Model of Autism
Samiha Sayed Sharna, Gayathri K Balasuriya, Suzanne Hosie, Jess Nithianantharajah, Ashley E Franks, Elisa L Hill-Yardin
Frontiers in Cellular Neuroscience | FRONTIERS MEDIA SA | Published : 2020
Abstract
The intrinsic nervous system of the gut interacts with the gut-associated lymphoid tissue (GALT) via bidirectional neuroimmune interactions. The caecum is an understudied region of the gastrointestinal (GI) tract that houses a large supply of microbes and is involved in generating immune responses. The caecal patch is a lymphoid aggregate located within the caecum that regulates microbial content and immune responses. People with Autism Spectrum Disorder (ASD; autism) experience serious GI dysfunction, including inflammatory disorders, more frequently than the general population. Autism is a highly prevalent neurodevelopmental disorder defined by the presence of repetitive behavior or restri..
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Awarded by Australian Research Council
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the Australian Research Council Future Fellowship (FT160100126) to EH-Y and National Health and Medical Research Council Project Grant (APP1083334) and Australian Research Council Future Fellowship (FT140101327) to JN. EH-Y also received an RMIT Vice Chancellor's Senior Research Fellowship, which supported GB and SH. The Hu antibody was a gift from Dr. V. Lennon, Mayo Clinic, USA.