Altered Caecal Neuroimmune Interactions in the Neuroligin-3(R451C) Mouse Model of Autism
Samiha Sayed Sharna, Gayathri K Balasuriya, Suzanne Hosie, Jess Nithianantharajah, Ashley E Franks, Elisa L Hill-Yardin
Frontiers in Cellular Neuroscience | FRONTIERS MEDIA SA | Published : 2020
The intrinsic nervous system of the gut interacts with the gut-associated lymphoid tissue (GALT) via bidirectional neuroimmune interactions. The caecum is an understudied region of the gastrointestinal (GI) tract that houses a large supply of microbes and is involved in generating immune responses. The caecal patch is a lymphoid aggregate located within the caecum that regulates microbial content and immune responses. People with Autism Spectrum Disorder (ASD; autism) experience serious GI dysfunction, including inflammatory disorders, more frequently than the general population. Autism is a highly prevalent neurodevelopmental disorder defined by the presence of repetitive behavior or restri..View full abstract
Awarded by Australian Research Council
Awarded by National Health and Medical Research Council
This work was supported by the Australian Research Council Future Fellowship (FT160100126) to EH-Y and National Health and Medical Research Council Project Grant (APP1083334) and Australian Research Council Future Fellowship (FT140101327) to JN. EH-Y also received an RMIT Vice Chancellor's Senior Research Fellowship, which supported GB and SH. The Hu antibody was a gift from Dr. V. Lennon, Mayo Clinic, USA.