Journal article

Comparison of Optimization-Modelling Methods for Metabolites Production in Escherichia coli

Mee K Lee, Mohd Saberi Mohamad, Yee Wen Choon, Kauthar Mohd Daud, Nurul Athirah Nasarudin, Mohd Arfian Ismail, Zuwairie Ibrahim, Suhaimi Napis, Richard O Sinnott

Journal of Integrative Bioinformatics | Walter de Gruyter | Published : 2020


The metabolic network is the reconstruction of the metabolic pathway of an organism that is used to represent the interaction between enzymes and metabolites in genome level. Meanwhile, metabolic engineering is a process that modifies the metabolic network of a cell to increase the production of metabolites. However, the metabolic networks are too complex that cause problem in identifying near-optimal knockout genes/reactions for maximizing the metabolite’s production. Therefore, through constraint-based modelling, various metaheuristic algorithms have been improvised to optimize the desired phenotypes. In this paper, PSOMOMA was compared with CSMOMA and ABCMOMA for maximizing the production..

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Awarded by Ministry of Education Malaysia

Funding Acknowledgements

We would like to thank the Ministry of Education Malaysia for supporting this re-search by the Fundamental Research Grant Scheme - Malaysia's Research Star Award - FRGS-MRSA (grant number: R/FRGS/A0800/01655A/003/2020/00720) and Fundamental Research Grant Schemes (grant number: RDU190113 and R.J130000.7828.4F720).