The Effect of Patient-and Treatment-Related Factors on Circuit Lifespan during Continuous Renal Replacement Therapy in Critically Ill Children

Abstract

Objectives: To examine the effects of patient and treatment variables on circuit lifespan in critically ill children requiring continuous renal replacement therapy. Design: Retrospective observational study based on a prospective registry. Setting: Tertiary referral 30-bed PICU. Patients: One hundred sixty-one critically ill children undergoing continuous renal replacement therapy during an 8-year period (2007-2014) were included in the study. Interventions: Continuous renal replacement therapy. Measurements and Main Results: During the study period, 161 patients received a total of 22,190 hours of continuous renal replacement therapy, with a median duration of 74.75 hours (interquartile ran..