Associations of childhood adiposity with menstrual irregularity and polycystic ovary syndrome in adulthood: the Childhood Determinants of Adult Health Study and the Bogalusa Heart Study
Y He, J Tian, L Blizzard, WH Oddy, T Dwyer, LA Bazzano, M Hickey, EW Harville, AJ Venn
Human Reproduction | OXFORD UNIV PRESS | Published : 2020
STUDY QUESTION: Is high adiposity in childhood associated with menstrual irregularity and polycystic ovary syndrome (PCOS) in later life? SUMMARY ANSWER: Overall, greater childhood BMI was associated with menstrual irregularity, and greater childhood BMI and waist/height ratio (WHtR) in white but not black participants were associated with PCOS in adulthood. WHAT IS KNOWN ALREADY: Increased childhood BMI has been associated with irregular menstrual cycles and PCOS symptoms in adulthood in two longitudinal population-based studies, but no study has reported on associations with childhood abdominal obesity. Few studies have investigated whether there are racial differences in the associations ..View full abstract
Awarded by National Health and Medical Research Council
Awarded by National Institutes of Health
The CDAH study was supported by grants from the National Health and Medical Research Council (grants 211316, 544923 and 1128373). The Bogalusa Heart Study is supported by National Institutes of Health grants R01HD069587, AG16592, HL121230, HD032194 and P50HL015103.