Journal article

Molecular imaging of atherosclerosis: spotlight on Raman spectroscopy and surface-enhanced Raman scattering

Neil MacRitchie, Gianluca Grassia, Jonathan Noonan, Paul Garside, Duncan Graham, Pasquale Maffia



To accurately predict atherosclerotic plaque progression, a detailed phenotype of the lesion at the molecular level is required. Here, we assess the respective merits and limitations of molecular imaging tools. Clinical imaging includes contrast-enhanced ultrasound, an inexpensive and non-toxic technique but with poor sensitivity. CT benefits from high spatial resolution but poor sensitivity coupled with an increasing radiation burden that limits multiplexing. Despite high sensitivity, positron emission tomography and single-photon emission tomography have disadvantages when applied to multiplex molecular imaging due to poor spatial resolution, signal cross talk and increasing radiation dose..

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Awarded by Engineering and Physical Sciences Research Council (EPSRC)

Awarded by European Commission

Awarded by British Heart Foundation

Awarded by Tenovus Scotland PROJECT

Awarded by Engineering and Physical Sciences Research Council

Funding Acknowledgements

This commissioned review article was written on behalf of the British Society for Cardiovascular Research. The authors work is funded by the Engineering and Physical Sciences Research Council (EPSRC) grant EP/L014165/1; the European Commission Marie Sklodowska-Curie Individual Fellowships 661369; the British Heart Foundation grant RE/13/5/30177 and the Tenovus Scotland PROJECT S15/24.