Journal article

The aorta can act as a site of naive CD4 T-cell priming

Neil MacRitchie, Gianluca Grassia, Jonathan Noonan, Jennifer E Cole, Catherine E Hughes, Juliane Schroeder, Robert A Benson, Clement Cochain, Alma Zernecke, Tomasz J Guzik, Paul Garside, Claudia Monaco, Pasquale Maffia

CARDIOVASCULAR RESEARCH | OXFORD UNIV PRESS | Published : 2020

Abstract

AIMS: Aortic adaptive immunity plays a role in atherosclerosis; however, the precise mechanisms leading to T-cell activation in the arterial wall remain poorly understood. METHODS AND RESULTS: Here, we have identified naïve T cells in the aorta of wild-type and T-cell receptor transgenic mice and we demonstrate that naïve T cells can be primed directly in the vessel wall with both kinetics and frequency of T-cell activation found to be similar to splenic and lymphoid T cells. Aortic homing of naïve T cells is regulated at least in part by the P-selectin glycosylated ligand-1 receptor. In experimental atherosclerosis the aorta supports CD4+ T-cell activation selectively driving Th1 polarizati..

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Grants

Awarded by British Heart Foundation


Awarded by Engineering and Physical Sciences Research Council (EPSRC)


Awarded by European Commission Marie Sklodowska-Curie [Individual Fellowships]


Funding Acknowledgements

This work was supported by the British Heart Foundation grants [PG/12/81/29897 to P.M., RE/13/5/30177]; the Engineering and Physical Sciences Research Council (EPSRC) grant [EP/L014165/1 to P.M.]; the European Commission Marie Sklodowska-Curie [Individual Fellowships 661369 to P.M.]; and Wellcome Trust Institutional Strategic Support Fund (ISSF) to P.M.