Journal article
HBV variants are common in the ‘immune-tolerant’ phase of chronic hepatitis B
L Yuen, PA Revill, G Rosenberg, J Wagner, M Littlejohn, J Bayliss, K Jackson, SK Tan, A Gaggar, K Kitrinos, M Subramanian, E Gane, HLY Chan, X Li, S Bowden, S Locarnini, A Thompson
Journal of Viral Hepatitis | WILEY | Published : 2020
DOI: 10.1111/jvh.13318
Abstract
Nucleos(t)ide analogues (NUC) treatment prevents progression of liver fibrosis in subjects with chronic hepatitis B (CHB). However, risk of hepatocellular carcinoma (HCC) persists despite viral suppression. Specific HBV variants have been associated with adverse outcomes, including HCC; however, the frequency of these variants during the seemingly benign immunotolerant (IT) phase is unknown. Next-generation sequencing and detailed virological characterization on a cohort of treatment-naïve IT subjects were performed to determine the frequency of clinically relevant viral variants. Samples from 97 subjects (genotype B/C 55%/45%, median HBV-DNA 8.5 log10 IU/mL, median HBsAg 4.8 log10 IU/mL, me..
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Funding Acknowledgements
The study was funded in part by Gilead Sciences.