Journal article

Joint impact of common risk factors on incident dementia: A cohort study of the Swedish Twin Registry

Y Tomata, X Li, IK Karlsson, MA Mosing, NL Pedersen, S Hagg

Journal of Internal Medicine | Wiley | Published : 2020

Abstract

Background As common risk factors of dementia, nine factors (low education, hearing loss, obesity, hypertension, smoking, depression, physical inactivity, diabetes and social isolation) were proposed. However, the joint impact of these factors on incident dementia is still uncertain; hence, we aimed to examine this impact. Methods We conducted a cohort study of 9017 cognitively intact individuals aged ≥ 65 years in the Swedish Twin Registry. The main exposure was the total number of reported risk factors (ranging from 0 to 9). Data on dementia diagnoses were based on clinical workup and national health registers. After estimating the adjusted hazard ratios of incident dementia, the populati..

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Grants

Awarded by Swedish Council for Working Life and Social Research (FORTE)


Awarded by Swedish Research Council


Funding Acknowledgements

This work was supported by the Swedish Council for Working Life and Social Research (FORTE) (2013-2292), the Swedish Research Council (2015-03255), King Gustaf V's and Queen Victoria's Freemason Foundation, the Strategic Research Area in Epidemiology at Karolinska Institutet and the Leading Young Researcher Overseas Visit Program from Tohoku University, Japan. This was an investigator-initiated study. The sponsor and funders of the study had no role in study design, data collection, data analysis, data interpretation or writing of the report.