Journal article
Biological sex classification with structural MRI data shows increased misclassification in transgender women
C Flint, K Förster, SA Koser, C Konrad, P Zwitserlood, K Berger, M Hermesdorf, T Kircher, I Nenadic, A Krug, BT Baune, K Dohm, R Redlich, N Opel, V Arolt, T Hahn, X Jiang, U Dannlowski, D Grotegerd
Neuropsychopharmacology | SPRINGERNATURE | Published : 2020
Abstract
Transgender individuals (TIs) show brain-structural alterations that differ from their biological sex as well as their perceived gender. To substantiate evidence that the brain structure of TIs differs from male and female, we use a combined multivariate and univariate approach. Gray matter segments resulting from voxel-based morphometry preprocessing of N = 1753 cisgender (CG) healthy participants were used to train (N = 1402) and validate (20% holdout N = 351) a support-vector machine classifying the biological sex. As a second validation, we classified N = 1104 patients with depression. A third validation was performed using the matched CG sample of the transgender women (TW) application ..
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Awarded by Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg
Funding Acknowledgements
This work was funded by the German Research Foundation (DFG, grant FOR2107 DA1151/5-1 and DA1151/5-2 to UD; SFB-TRR58, Projects C09 and Z02 to UD) and the Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Munster (grant Dan3/012/17 to UD). The BiDirect Study is supported by a grant of the German Ministry of Research and Education (BMBF) to the University of Muenster (01ER0816 and 01ER1506).