Journal article

Minimizing axon bundle activation of retinal ganglion cells with oriented rectangular electrodes.

Wei Tong, Maryam Hejazi, David J Garrett, Timothy Esler, Steven Prawer, Hamish Meffin, Michael Ibbotson

Journal of Neural Engineering | IOP Publishing | Published : 2020

Abstract

OBJECTIVE: Retinal prostheses aim to restore vision in patients with retinal degenerative diseases, such as age-related macular degeneration and retinitis pigmentosa. By implanting an array of microelectrodes, such a device creates percepts in patients through electrical stimulation of surviving retinal neurons. A challenge for retinal prostheses when trying to return high quality vision is the unintended activation of retinal ganglion cells through the stimulation of passing axon bundles, which leads to patients reporting large, elongated patches of light instead of focal spots. APPROACH: In this work, we used calcium imaging to record the responses of retinal ganglion cells to electrical s..

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Grants

Awarded by National Health and Medical Research Council


Funding Acknowledgements

The research was supported by a Development Grant from The National Health and Medical Research Council (NHMRC, GNT1118223) of Australia. The work was performed in part at the Melbourne Centre for Nanofabrication (MCN) in the Victorian Node of the Australian National Fabrication Facility (ANFF). D J G is supported by NHMRC Project Grant GNT1101717 and by an Australian Nanofabrication Facility (ANFF)/Melbourne Centre for Nanofabrication (MCN) Technology Ambassador Fellowship. S P is cofounder and shareholder of iBIONICS, a company developing a diamond based retinal prothesis. S P and D J G are shareholders and executive officers of Carbon Cybernetics Pty Ltd, a company developing diamond and carbon-based medical device components. The other authors declare no conflict of interest.