Journal article

Focal duodenal necrosis in chickens: attempts to reproduce the disease experimentally and diagnostic considerations

Ana M Villegas, Lisa Stabler, Robert J Moore, Francisco A Uzal, Jake A Lacey, Charles Hofacre, Margie Lee, Naola Ferguson-Noel, Rosetta Barber, Claire-Sophie Rimet, Carmen Jerry, Woo Kyun Kim, Barquiesha Madison, Monique Franca

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION | SAGE PUBLICATIONS INC | Published : 2020

Abstract

Focal duodenal necrosis (FDN) is an intestinal disease of egg-layer chickens characterized by multifocal necrosis of the duodenal loop and proximal jejunum. Affected flocks usually have decreased egg weights and drops in egg production. Previous studies have associated this condition with Clostridium perfringens infection. We tried to reproduce FDN by experimental infection of egg-laying chickens using different netB-positive and netB-negative C. perfringens strains, and duodenal homogenate obtained from FDN lesions. Chickens challenged with C. perfringens and/or duodenal homogenate developed duodenitis after challenge. Gross lesions included mucosal erosions, hyperemia, mucosal hemorrhages,..

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Funding Acknowledgements

This work was funded by the Egg Industry Center located at Iowa State University in Ames, IA. Opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the Egg Industry Center or Iowa State University.