Journal article

Characterization of the immune profile of oral tongue squamous cell carcinomas with advancing disease

Katie Meehan, Connull Leslie, Michaela Lucas, Angela Jacques, Bob Mirzai, James Lim, Max Bulsara, Yasir Khan, Nicholas C Wong, Benjamin Solomon, Chady Sader, Peter Friedland, Gisela Mir Arnau, Timothy Semple, Annette M Lim

Cancer Medicine | WILEY | Published : 2020

Abstract

We investigated whether a unique immune response was instigated with the development of oral tongue squamous cell carcinomas (OTSCC), with/without nodal involvement, with/without recurrent metastatic disease, or within tumor involved nodes. One hundred and ten formalin-fixed paraffin-embedded samples were collected from a retrospective cohort of 67 OTSCC patients and 10 non-cancerous tongue samples. Targets including CD4, CD8, FOXP3, PD-L1, and PD-1 were analyzed by immunohistochemistry. The Nanostring PanCancer Immune Profiling Panel was used for gene expression profiling. Data were externally validated in the The Cancer Genome Atlas (TCGA) head and neck (HNSCC), melanoma and lung squamous ..

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Grants

Funding Acknowledgements

Department of Health (WA)/Raine Medical Research Foundation; Garnett Passe and Rodney Williams Memorial Foundation; Royal Australasian College of Physicians; Cancer Council Western Australia; Western Australian Department of Health