Dietary fiber-based colon-targeted delivery systems for polyphenols

Abstract

Background: Natural polyphenols have potential therapeutic effects on colon-based diseases and gut microbial dysbiosis. However, the delivery of pure polyphenols to the colon has to overcome chemical instability, degradation, and metabolism in the upper gastrointestinal tract after oral ingestion. Dietary fibers have been exploited as microbiota-triggered release systems to protect polyphenols in the upper gut and specifically deliver them to the colon. Scope and approach: This review focuses on the recent development of colon-targeted polyphenol delivery systems using encapsulation technologies based on dietary fibers for both food and pharmaceutical applications. The detailed characterist..