Journal article

Therapeutic ISCOMATRIX (TM) adjuvant vaccine elicits effective anti-tumor immunity in the TRAMP-C1 mouse model of prostate cancer

Adele M Barr, Anabel Silva, Sandro Prato, Gabrielle T Belz, Eugene Maraskovsky, Adriana Baz Morelli

Cancer Immunology, Immunotherapy | SPRINGER | Published : 2020

Abstract

Cancer vaccine development has proven challenging with the exception of some virally induced cancers for which prophylactic vaccines exist. Currently, there is only one FDA approved vaccine for the treatment of prostate cancer and as such prostate cancer continues to present a significant unmet medical need. In this study, we examine the effectiveness of a therapeutic cancer vaccine that combines the ISCOMATRIX™ adjuvant (ISCOMATRIX) with the Toll-like receptor 3 agonist, polyinosinic-polycytidylic acid (Poly I:C), and Flt3L, FMS-like tyrosine kinase 3 ligand. We employed the TRAMP-C1 (transgenic adenocarcinoma of the mouse prostate) model of prostate cancer and the self-protein mPAP (prosta..

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Grants

Awarded by National Health and Medical Research Council Fellowship


Awarded by National Health and Medical Research Council (NHMRC) of Australia


Funding Acknowledgements

At the time of completing this work, Adele Barr was the recipient of National Health and Medical Research Council Fellowship CDA APP1006663. Gabrielle T. Belz is supported by a fellowship from the National Health and Medical Research Council (NHMRC) of Australia (APP1135898).