Journal article

Examining the Effects of Anabolic-Androgenic Steroids on Repetitive Mild Traumatic Brain Injury (RmTBI) Outcomes in Adolescent Rats

Jason Tabor, David K Wright, Jennaya Christensen, Akram Zamani, Reid Collins, Sandy R Shultz, Richelle Mychasiuk

Brain Sciences | MDPI | Published : 2020

Abstract

Background: Repetitive mild traumatic brain injury (RmTBI) is increasingly common in adolescents. Anabolic–androgenic steroid (AAS) consumption among younger professional athletes is a significant risk factor for impaired neurodevelopment. Given the increased rates and overlapping symptomology of RmTBI and AAS use, we sought to investigate the behavioural and neuropathological outcomes associated with the AAS Metandienone (Met) and RmTBI on rats. Methods: Rats received either Met or placebo and were then administered RmTBIs or sham injuries, followed by a behavioural test battery. Post-mortem MRI was conducted to examine markers of brain integrity and qRT-PCR assessed mRNA expression of mark..

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Grants

Awarded by Canadian Institutes of Health Research (CIHR)


Awarded by Natural Sciences and Engineering Research Council of Canada (NSERC)


Funding Acknowledgements

This study was supported by the Canadian Institutes of Health Research (CIHR) grant number: PJT-153051 and Natural Sciences and Engineering Research Council of Canada (NSERC) grant number: 1304881.