Journal article

Biphasic Outbreak of Invasive Group A Streptococcus Disease in Eldercare Facility, New Zealand

Kate A Worthing, Anja Werno, Ramon Pink, Liam McIntyre, Glen P Carter, Deborah A Williamson, Mark R Davies

EMERGING INFECTIOUS DISEASES | CENTERS DISEASE CONTROL & PREVENTION | Published : 2020

Abstract

A 3-month outbreak of invasive group A Streptococcus disease at an eldercare facility, in which 5 persons died, was biphasic. Although targeted chemoprophylaxis contained the initial outbreak, a second phase of the outbreak occurred after infection control processes ended. To retrospectively investigate the genomic epidemiology of the biphasic outbreak, we used whole-genome sequencing and multiple bioinformatics approaches. Analysis of isolates from the outbreak and isolates prospectively collected during the outbreak response indicated a single S. pyogenes emm81 clone among residents and staff members. Outbreak isolates differed from nonoutbreak emm81 isolates by harboring an integrative co..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Early Career Fellowship


Funding Acknowledgements

This work was supported by The Wellcome Trust, UK, and the National Health and Medical Research Council of Australia (grant no. 1130455), and an Early Career Fellowship (GNT1123854 to D.A.W.)