Journal article

The Detection of Bile Acids in the Lungs of Paediatric Cystic Fibrosis Patients Is Associated with Altered Inflammatory Patterns

Jose A Caparros-Martin, Stephanie Flynn, F Jerry Reen, David F Woods, Patricia Agudelo-Romero, Sarath C Ranganathan, Stephen M Stick, Fergal O'Gara

Diagnostics | MDPI AG | Published : 2020


Background: Cystic fibrosis (CF) is a hereditary disorder in which persistent unresolved inflammation and recurrent airway infections play major roles in the initiation and progression of the disease. Little is known about triggering factors modulating the transition to chronic microbial infection and inflammation particularly in young children. Cystic fibrosis respiratory disease starts early in life, with the detection of inflammatory markers and infection evident even before respiratory symptoms arise. Thus, identifying factors that dysregulate immune responsiveness at the earliest stages of the disease will provide novel targets for early therapeutic intervention. Methods: We evaluated t..

View full abstract


Awarded by European Commission

Awarded by Science Foundation Ireland

Awarded by Department of Agriculture and Food (FIRM/RSF/CoFoRD)

Awarded by Irish Research Council for Science, Engineering and Technology

Awarded by Health Research Board/Irish Thoracic Society

Awarded by Marine Institute (Beaufort award C2CRA)

Awarded by US CF Foundation

Funding Acknowledgements

This research was supported in part by grants awarded by the European Commission (FP7-PEOPLE-2013-ITN, 607786; FP7-KBBE-2012-6, CP-TP-312184; FP7-KBBE-2012-6, 311975; OCEAN 2011-2, 287589; Marie Curie 256596; EU-634486), Science Foundation Ireland (SSPC-2, 12/RC/2275; -SSP3-Pharm5:13/TIDA/B2625; 12/TIDA/B2411; 12/TIDA/B2405; 14/TIDA/2438, 15/TIDA/2977), the Department of Agriculture and Food (FIRM/RSF/CoFoRD; FIRM 08/RDC/629; FIRM 1/F009/MabS; FIRM 13/F/516), the Irish Research Council for Science, Engineering and Technology (PD/2011/2414; GOIPG/2014/647), the Health Research Board/Irish Thoracic Society (MRCG-2014-6 and MRCG-2018-16) & HRB-ILP-POR-2019-004, The Marine Institute (Beaufort award C2CRA 2007/082) and Teagasc (Walsh Fellowship 2013), The Glenn Brown Memorial Grant 2017 (The Institute for Respiratory Health, Perth, Australia), and the US CF Foundation (Grant CFF 1710).