Journal article
Diagnostic ability of multifocal electroretinogram in early multiple sclerosis using a new signal analysis method
L Boquete, E López-Guillén, E Vilades, JM Miguel-Jiménez, LE Pablo, L de Santiago, MO del Castillo, MC Alonso-Rodríguez, EMS Morla, A López-Dorado, E Garcia-Martin
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2019
Open access
Abstract
Purpose To determine if a novel analysis method will increase the diagnostic value of the multifocal electroretinogram (mfERG) in diagnosing early-stage multiple sclerosis (MS). Methods We studied the mfERG signals of OD (Oculus Dexter) eyes of fifteen patients diagnosed with early-stage MS (in all cases < 12 months) and without a history of optic neuritis (ON) (F: M = 11:4), and those of six controls (F:M = 3:3). We obtained values of amplitude and latency of N1 and P1 waves, and a method to assess normalized root-mean-square error (FNRMSE) between model signals and mfERG recordings was used. Responses of each eye were analysed at a global level, and by rings, quadrants and hemispheres. AUC..
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Awarded by Federación Española de Enfermedades Raras
Funding Acknowledgements
This work was supported by the Carlos III Health Institute [grant number PI17/01726, "Neuro-ophthalmological evaluation as a biomarker of diagnosis, monitoring and prognosis in multiple sclerosis", to EGM]; Secretary of State for Research, Development and Innovation [grant number DPI2017-88438-R (AEI/FEDER, UE) to LB] and RETICS Oftared, RD16/0008/020 to LB and RD16/0008/029 to EGM. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.