Journal article

Expanding the Role for Immunotherapy in Triple-Negative Breast Cancer

Peter Savas, Sherene Loi

Cancer Cell | CELL PRESS | Published : 2020

Abstract

PD-1 axis blockade, in combination with chemotherapy, improves outcomes in advanced triple-negative breast cancer that is PD-L1 positive. The phase 3 KEYNOTE-522 trial now shows that the addition of pembrolizumab to chemotherapy improves pathological complete response rates regardless of PD-L1 status and appears to improve survival.

Grants

Funding Acknowledgements

S.L. is supported by National Breast Cancer Foundation (NBCF) of Australia and the Breast Cancer Research Foundation (BCRF).