Journal article
Association between Patient-Reported Outcomes and Time to Late Age-Related Macular Degeneration in the Laser Intervention in Early Stages of Age-Related Macular Degeneration Study.
Myra B McGuinness, Robert P Finger, Zhichao Wu, Chi D Luu, Fred K Chen, Jenifer J Arnold, Usha Chakravarthy, Robyn H Guymer, undefined Laser Intervention in Early Stages of Age-Related Macular Degeneration Study Group
Ophthalmology Retina | Elsevier | Published : 2020
Abstract
PURPOSE: To investigate the relationship between patient-reported outcome (PRO) questionnaire responses and time to late age-related macular degeneration (AMD; neovascular AMD [nAMD] or multimodal imaging [MMI]-defined atrophy) among individuals with bilateral large drusen, and the prognostic value of baseline PROs for 36-month AMD status. DESIGN: Exploratory analyses from a multicenter randomized controlled trial of an AMD intervention (Australian New Zealand Clinical Trials Registry identifier, ACTRN12612000704897). PARTICIPANTS: Sham treatment group of the Laser Intervention in Early Stages of Age-Related Macular Degeneration (LEAD) Study (n = 141; age, 50-88 years; 77% female). METHODS: ..
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Awarded by Bupa Health Foundation
Funding Acknowledgements
The Laser Intervention in Early Stages of Age-Related Macular Degeneration (LEAD) Study was funded by the National Health and Medical Research Council of Australia (project grant no.: 1027624 [R.H.G. and C.D.L.); the BUPA Health Foundation, Australia; and Ellex Medical Lasers, Ltd., who also provided funds and the investigational devices. Supported by the National Health and Medical Research Council (principal research fellowship no.: 1103013 [R.H.G.]; fellowship grant no.: 1104985 [Z.W.]; early career fellowship no.: 1054712 [F.K.C.]; and career development fellowship no.: 1142962 [F.K.C.]); and the Victorian government and the National Health and Medical Research Council (Centre for Research Excellence grant 529923 [Centre for Eye Research Australia]). The funding organizations had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.