Journal article

Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction

Tu'uhevaha J Kaitu'u-Lino, Teresa M MacDonald, Ping Cannon, Nguyen Tuong-Vi, Richard J Hiscock, Nick Haan, Jenny E Myers, Roxanne Hastie, Kirsten M Dane, Anna L Middleton, Intissar Bittar, Amanda N Sferruzzi-Perri, Natasha Pritchard, Alesia Harper, Natalie J Hannan, Valerie Kyritsis, Nick Crinis, Lisa Hui, Susan P Walker, Stephen Tong

NATURE COMMUNICATIONS | NATURE PUBLISHING GROUP | Published : 2020

Abstract

Purpose To investigate the relationship between patient-reported outcome (PRO) questionnaire responses and time to late age-related macular degeneration (AMD; neovascular AMD [nAMD] or multimodal imaging [MMI]-defined atrophy) among individuals with bilateral large drusen, and the prognostic value of baseline PROs for 36-month AMD status. Design Exploratory analyses from a multicenter randomized controlled trial of an AMD intervention (Australian New Zealand Clinical Trials Registry identifier, ACTRN12612000704897). Participants Sham treatment group of the Laser Intervention in Early Stages of Age-Related Macular Degeneration (LEAD) Study (n = 141; age, 50–88 years; 77% female). Methods T..

View full abstract

Grants

Awarded by National Health and Medical Research Council


Funding Acknowledgements

We thank Sally Beard and Natalie Binder for technical assistance. We thank Emerson Keenan for statistical assistance. We also thank and acknowledge Abigail L. Fowden, Josephine S. Higgins and Owen R. Vaughan for their involvement in design and execution of the mouse studies. We thank Gabrielle Pell, Rachel Murdoch and Genevieve Christophers, Elizabeth Lockie and Emma McLaughlin for their assistance in recruiting and characterizing participants. We acknowledge Alice Robinson for her ultrasound assistance. We also wish to thank the pathology, health information services, and antenatal clinic staff at the Mercy Hospital for Women for their assistance in conducting this research. Funding for this work was provided by the National Health and Medical Research Council (#1065854, #1183854), Foresight Health, The Stillbirth Foundation and the Norman Beischer Medical Research Foundation; Australian Government Research Training Program Scholarship, and RANZCOG Taylor Hammond Scholarship to T.M.M.; National Health and Medical Research Council Fellowships to T.K.L. (#1159261), S.T. (#1136418), L.H. (#1105603), and N.H. (#1146128). Funding for the mouse work was provided by a PhD studentship, an In Vivo Skills award from the Biotechnology and Biological Sciences Research Council. In addition, the mouse work was supported by a Next Generation fellowship to A.S.P. and PhD studentship from the Centre for Trophoblast Research. The MAViS clinic and research cohort received funding from National Institute Health Research and Tommys Charity and is supported by the Manchester Academic Health Science Centre.