Calciprotein particles: mineral behaving badly?
Edward R Smith, Tim D Hewitson, Willi Jahnen-Dechent
Current Opinion in Nephrology & Hypertension | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020
PURPOSE OF REVIEW: Calciprotein particles (CPP) are formed in supersaturated solutions of calcium, phosphate and the mineral-binding protein fetuin-A. CPP have garnered considerable interest as potential mediators of mineral stress, but little consideration has been given to their origin, clearance and role in metabolism. RECENT FINDINGS: CPP are made whilst buffering the mineral absorbed from the intestine after a meal or during remodelling of bone matrix. The postprandial rise in circulating CPP rise may be sensed by osteoblasts/osteocytes in bone, stimulating the secretion of the master phosphatonin fibroblast growth factor 23. Amorphous calcium phosphate-containing CPP are rapidly cleare..View full abstract
E. R.S. and T.D.H. are supported by a Royal Melbourne Hospital Home Lottery Project Grant and funding from Sanofi. W.J.D. was supported by grants from Deutsche Forschungsgemeinschaft and the Interdisciplinary Center for Clinical Research of the Medical Faculty of RWTH Aachen University.