The tumor immune microenvironment of germline BRCA1/2 and sporadic prostate cancer

Anna S Trigos; Anupama Pasam; Patricia Diana Banks; Roslyn Wallace; Simon P Keam; Heather Thorne; Catherine Mitchell; David Clouston; Declan G Murphy; Nathan Lawrentschuk; Damien M Bolton; Daniel Moon; Elena Castro; David Olmos; Phillip K Darcy; Ygal Haupt; Scott Williams; David L Goode; Paul J Neeson; Shahneen Kaur Sandhu

Conference Proceedings

The tumor immune microenvironment of germline BRCA1/2 and sporadic prostate cancer

Anna S Trigos, Anupama Pasam, Patricia Diana Banks, Roslyn Wallace, Simon P Keam, Heather Thorne, Catherine Mitchell, David Clouston, Declan G Murphy, Nathan Lawrentschuk, Damien M Bolton, Daniel Moon, Elena Castro, David Olmos, Phillip K Darcy, Ygal Haupt, Scott Williams, David L Goode, Paul J Neeson, Shahneen Kaur Sandhu

JOURNAL OF CLINICAL ONCOLOGY | AMER SOC CLINICAL ONCOLOGY | Published : 2020

DOI: 10.1200/jco.2020.38.6_suppl.152

Abstract

152 Background: Prostate cancer (PC) is considered an immunologically ‘cold’ tumor and therefore patients are generally not considered good candidates for immunotherapy. Tumors arising in germline (g) BRCA1/2 mutation carriers are associated with higher genomic instability and levels of immune infiltration in breast and ovarian cancer. We investigated how germline mutations in DNA repair genes affect the tumor immune microenvironment (TME) of PC. Methods: Archival primary tumor samples from 26 patients with g BRCA2 mutations, 5 with g BRCA1, 5 with mutations in other DNA repair genes ( ATM, CHEK2, FANCI, PALB2 or BRCA2+ MSH2), and 26 sporadic patients were analyzed. OPAL multiplex immunohis..

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