Association of Myopia and Intraocular Pressure With Retinal Detachment in European Descent Participants of the UK Biobank Cohort A Mendelian Randomization Study
Xikun Han, Jue-Sheng Ong, Jiyuan An, Jamie E Craig, Puya Gharahkhani, Alex W Hewitt, Stuart MacGregor
JAMA Ophthalmology | AMER MEDICAL ASSOC | Published : 2020
Importance: Rhegmatogenous retinal detachment is a potentially sight-threatening condition. The role of myopia or intraocular pressure (IOP) in retinal detachment remains unclear. Objective: To determine if myopia or IOP is associated with retinal detachment risk using genetic data. Design, Setting, and Participants: Observational analyses and 2-sample mendelian randomization were used to evaluate the associations between myopia, IOP, and retinal detachment risk in European descent participants from the UK Biobank (UKBB) cohort (n = 405 692). For retinal detachment, a genome-wide association study on 4257 cases and 39 181 controls in the UKBB was conducted. Genetic variants associated with m..View full abstract
Awarded by Australian National Health and Medical Research Council
This work was conducted using the UK Biobank Resource (application number 25331). Drs Craig, Hewitt, and MacGregor are supported by Australian National Health and Medical Research Council Fellowships. Mr Han is supported by the University of Queensland Research Training Scholarship and QIMR Berghofer PhD Top Up Scholarship. We acknowledge funding from Australian National Health and Medical Research Council grants 1116360, 1150144, and 1123248.