Journal article

Subjective cognitive decline and subsequent dementia: a nationwide cohort study of 579,710 people aged 66 years in South Korea

Yeong Chan Lee, Jae Myeong Kang, Hyewon Lee, Kiwon Kim, Soyeon Kim, Tae Yang Yu, Eun-Mi Lee, Clara Tammy Kim, Doh Kwan Kim, Matthew Lewis, Hong-Hee Won, Frank Jessen, Woojae Myung



Background Subjective cognitive decline (SCD) is a potential risk factor for dementia. We aimed to investigate the association between SCD and subsequent dementia in a nationwide population-based cohort in South Korea. Methods This cohort included 579,710 66-year-old adults who were followed for a total of 3,870,293 person-years (average 6.68 ± 1.33 years per person). All subjects completed a questionnaire about subjective memory impairment, the Pre-screening Korean Dementia Screening Questionnaire (KDSQ-P), which included a validated 5-item derivative, and were determined to have SCD based on a single question assessing memory decline. Depressive symptoms were assessed in all subjects usin..

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University of Melbourne Researchers


Awarded by National Research Foundation (NRF) of Korea Grant - Korean government

Awarded by Basic Science Research Program through the NRF of Korea - Ministry of Education

Awarded by NRF - Korean government (MSIT)

Funding Acknowledgements

This work was supported by a National Research Foundation (NRF) of Korea Grant, funded by the Korean government (NRF-2018R1C1B6001708; WM); the Basic Science Research Program through the NRF of Korea, funded by the Ministry of Education (NRF-2018R1D1A1B07049034; HL); and an NRF grant funded by the Korean government (MSIT, NRF-2019R1A2C4070496; HHW). The funding sources had no role in the study design; collection, analysis, and interpretation of the data; writing of the report; or decision to submit the article for publication. All researchers are independent of relationships with the funders, and all authors, external and internal, had full access to the study's data and can take responsibility for the integrity of the data and the accuracy of the data analysis.