Journal article

HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer

Holly Brunton, Giuseppina Caligiuri, Richard Cunningham, Rosie Upstill-Goddard, Ulla-Maja Bailey, Ian M Garner, Craig Nourse, Stephan Dreyer, Marc Jones, Kim Moran-Jones, Derek W Wright, Viola Paulus-Hock, Colin Nixon, Gemma Thomson, Nigel B Jamieson, Grant A McGregor, Lisa Evers, Colin J McKay, Aditi Gulati, Rachel Brough Show all

Cell Reports | CELL PRESS | Published : 2020

University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by NIH


Awarded by NHMRC


Awarded by Cancer Australia


Awarded by Cancer Research UK


Awarded by Wellcome Trust


Awarded by Pancreatic Cancer UK Future Research Leaders Fund


Awarded by Associazione Italiana Ricerca Cancro


Awarded by FP7 European Community


Awarded by Italian Ministry of Health


Awarded by CRUK Glasgow Centre


Awarded by Core Services at the Cancer Research UK Beatson Institute


Awarded by Susan Wojcicki and Dennis Tropper NIH grant


Awarded by Scottish Genome Partnership


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia (NHMRC; grants 631701, 535903, and 427601); American Association for Cancer Research (AACR) Landon Foundation-INNOVATOR Award; Susan Wojcicki and Dennis Tropper NIH grant CA62924; NIH (grants 5R01CA150190-07, P50 CA102701, and U01 CA224145); NHMRC (grants 1162860 and 1162556); Cancer Australia (grant 1143699); Cancer Research UK (grants C29717/A17263, C29717/A18484, C596/A18076, C596/A20921, A23526, A14276, A25233, and A29996); Wellcome Trust Senior Investigator Award (103721/Z/14/Z); Pancreatic Cancer UK Future Research Leaders Fund (FLF2015_04_Glasgow); Scottish Genome Partnership (SEHHD-CSO 1175759/2158447); Pancreatic Cancer Research Fund; MRC/EPSRC Glasgow Molecular Pathology Node; The Howat Foundation; Italian Cancer Genome Project-Ministry of University (FIRB RBAP10AHJB); Associazione Italiana Ricerca Cancro (grant 12182); FP7 European Community Grant Cam-Pac (grant 602783); Italian Ministry of Health (FIMP-CUP_ J33G13000210001); and ICGC Ontario Institute for Cancer Research. The mass spectrometry analysis was carried out at Glasgow Polyomics (University of Glasgow). The PDCLs were provided by the Australian Pancreatic Cancer Genome Initiative (APGI; https://www.pancreaticcancer.net.au/) and the Garvin Institute of Medical Research (Sydney, Australia). We would like to thank the CRUK Glasgow Centre (A25142) and Core Services at the Cancer Research UK Beatson Institute (A17196), with particular thanks to the Biological Services Unit and Histology. We are thankful to Catherine Winchester for editing the manuscript and to Kevin Ryan for insightful commentary.