Whole Genome Sequence Analysis and Population Genomics of Group A Streptococci

Jake A Lacey; Taylah B James; Steven YC Tong; Mark R Davies

Journal article

Whole Genome Sequence Analysis and Population Genomics of Group A Streptococci

Jake A Lacey, Taylah B James, Steven YC Tong, Mark R Davies, T Proft (ed.), JMS Loh (ed.)

GROUP A STREPTOCOCCUS | HUMANA PRESS INC | Published : 2020

DOI: 10.1007/978-1-0716-0467-0_7

Abstract

Whole-genome sequencing (WGS) is used to determine the genetic composition of an organism. This fast-moving field is continually evolving through technical advancements and the development of new bioinformatic tools for analyzing genomic data; however, the basic principles and processes for defining and processing high-quality genome sequence information remain unchanged. Here, we introduce some considerations and describe some commonly used bioinformatic steps for processing raw genome sequence data to generate genome assemblies through to understanding basic population genomics.

University of Melbourne Researchers

Steven Tong Author Infectious Diseases

Jake Lacey Author Infectious Diseases

Mark Davies Author Microbiology and Immunology

Related Projects (3)

OPTIMISING INTERVENTION STRATEGIES TO REDUCE THE BURDEN OF GROUP A STREPTOCOCCUS IN ABORIGINAL COMMUNITIES

Skin sores are highly prevalent in remote Australian Indigenous communities and can lead to invasive infections and rheumatic heart disease...

INTEROGATION OF THE GENOMIC EPIDEMIOLOGY AND NEPHRITOGENICITY WITHIN INDIGENOUS REGIONS ENDEMIC FOR GROUP A STREPTOCOCCAL DISEASE

Group A streptococcal (GAS) bacterial infections within the Indigenous populations of Northern Australia are amongst the highest in the worl..

CONTRIBUTION OF CARBOHYDRATE METABOLISM TO THE MAINTENANCE OF ENDEMIC STREPTOCOCCAL PATHOGENS

Group A streptococcal (GAS) bacterial infections within the Indigenous populations of Northern Australia are amongst the highest in the worl..

Grants

Awarded by NHMRC

Awarded by Australian National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

This work was supported by NHMRC project grants (#1130455, #1165876 and #1098319). S.Y.C.T. is an Australian National Health and Medical Research Council (NHMRC) Career Development Fellow (#1145033). M.R.D is an University of Melbourne C.R. Roper Fellow.