Journal article

Modulating the Selectivity and Stealth Properties of Ellipsoidal Polymersomes through a Multivalent Peptide Ligand Display

Kristel C Tjandra, Chelsea R Forest, Chin Ken Wong, Sheilajen Alcantara, Hannah G Kelly, Yi Ju, Martina H Stenzel, Joshua A McCarroll, Maria Kavallaris, Frank Caruso, Stephen J Kent, Pall Thordarson

Advanced Healthcare Materials | Wiley | Published : 2020

Abstract

There is a need for improved nanomaterials to simultaneously target cancer cells and avoid non‐specific clearance by phagocytes. An ellipsoidal polymersome system is developed with a unique tunable size and shape property. These particles are functionalized with in‐house phage‐display cell‐targeting peptide to target a medulloblastoma cell line in vitro. Particle association with medulloblastoma cells is modulated by tuning the peptide ligand density on the particles. These polymersomes has low levels of association with primary human blood phagocytes. The stealth properties of the polymersomes are further improved by including the peptide targeting moiety, an effect that is likely driven by..

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Grants

Awarded by Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by National Health and Medical Research Council Senior Principal Research Fellowship


Funding Acknowledgements

M.K., F.C., S.J.K, and P.T. were in part supported by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036) which also provided a PhD scholarship to K.T. This work was supported by grants from the Ross Trust Foundation (J.A.M.) and Steadfast Foundation (J.A.M.). J.A.M. was in part supported by funding from the Olivia Lambert Foundation. F.C. acknowledges the award of a National Health and Medical Research Council Senior Principal Research Fellowship (GNT1135806). The authors thank the staff of Mark Wainwright Analytical Centre at UNSW.