Journal article

Supporting pandemic response using genomics and bioinformatics: A case study on the emergent SARS-CoV-2 outbreak

Denis C Bauer, Aidan P Tay, Laurence OW Wilson, Daniel Reti, Cameron Hosking, Alexander J McAuley, Elizabeth Pharo, Shawn Todd, Vicky Stevens, Matthew J Neave, Mary Tachedjian, Trevor W Drew, Seshadri S Vasan

Transboundary and Emerging Diseases | WILEY | Published : 2020

Abstract

Pre-clinical responses to fast-moving infectious disease outbreaks heavily depend on choosing the best isolates for animal models that inform diagnostics, vaccines and treatments. Current approaches are driven by practical considerations (e.g. first available virus isolate) rather than a detailed analysis of the characteristics of the virus strain chosen, which can lead to animal models that are not representative of the circulating or emerging clusters. Here, we suggest a combination of epidemiological, experimental and bioinformatic considerations when choosing virus strains for animal model generation. We discuss the currently chosen SARS-CoV-2 strains for international coronavirus diseas..

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University of Melbourne Researchers

Grants

Funding Acknowledgements

Commonwealth Scientific and Industrial Research Organisation; Coalition for Epidemic Preparedness Innovations