Journal article

Isolating the sources of heterogeneity in nano-engineered particle-cell interactions.

Stuart T Johnston, Matthew Faria, Edmund J Crampin

Journal of the Royal Society Interface | The Royal Society | Published : 2020

Abstract

Nano-engineered particles have the potential to enhance therapeutic success and reduce toxicity-based treatment side effects via the targeted delivery of drugs to cells. This delivery relies on complex interactions between numerous biological, chemical and physical processes. The intertwined nature of these processes has thus far hindered attempts to understand their individual impact. Variation in experimental data, such as the number of particles inside each cell, further inhibits understanding. Here, we present a mathematical framework that is capable of examining the impact of individual processes during particle delivery. We demonstrate that variation in experimental particle uptake dat..

View full abstract