Journal article

Rice 3D chromatin structure correlates with sequence variation and meiotic recombination rate

Agnieszka A Golicz, Prem L Bhalla, David Edwards, Mohan B Singh

Communications Biology | NATURE RESEARCH | Published : 2020


Genomes of many eukaryotic species have a defined three-dimensional architecture critical for cellular processes. They are partitioned into topologically associated domains (TADs), defined as regions of high chromatin inter-connectivity. While TADs are not a prominent feature of A. thaliana genome organization, they have been reported for other plants including rice, maize, tomato and cotton and for which TAD formation appears to be linked to transcription and chromatin epigenetic status. Here we show that in the rice genome, sequence variation and meiotic recombination rate correlate with the 3D genome structure. TADs display increased SNP and SV density and higher recombination rate compar..

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Funding Acknowledgements

We would like to thank Dr Philipp Bayer for the valuable comments on the manuscript. This work was supported the University of Melbourne McKenzie Fellowship.