Protective effect of kava constituents in an in vitro model of oral mucositis
Callisthenis Yiannis, Kevin Huang, Nhien Tran An, Cathy Zeng, Emily Dao, Oliver Baselyous, Muaaz Adil Mithwani, Rita Paolini, Nicola Cirillo, Tami Yap, Michael McCullough, Antonio Celentano
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | SPRINGER | Published : 2020
PURPOSE: Oral mucositis is a debilitating inflammatory disorder observed in patients undergoing active cancer treatment, particularly cancer of the head and neck region. A key pathway believed to be involved in the pathogenesis of oral mucositis is the formation of reactive oxygen species (ROS). The identification of compounds that can inhibit this pathway may therefore be of benefit in treating this disorder. The kava plant (Piper methysticum) contains various constituents, including flavokawain A (FKA), flavokawain B (FKB), yangonin, methysticin and kavain. These constituents are known to be biologically active and possess anti-oxidative properties. This study therefore focused on examinin..View full abstract
This study was supported by the University of Melbourne-FA Kernot research grant (2018 F.A. Kernot Early to Mid-career Research Grant).