Journal article

Baseline White Matter Is Associated With Physical Fitness Change in Preclinical Alzheimer's Disease

Vijay K Venkatraman, Christopher E Steward, Kay L Cox, Kathryn A Ellis, Pramit M Phal, Matthew J Sharman, Victor L Villemagne, Michelle MY Lai, Elizabeth Cyarto, David Ames, Cassandra Szoeke, Christopher C Rowe, Colin L Masters, Nicola T Lautenschlager, Patricia M Desmond



White matter (WM) microstructure is a sensitive marker to distinguish individuals at risk of Alzheimer's disease. The association of objective physical fitness (PF) measures and WM microstructure has not been explored and mixed results reported with physical activity (PA). Longitudinal studies of WM with PA and PF measures have had limited investigation. This study explored the relationship between objective PF measures over 24-months with "normal-appearing" WM microstructure. Data acquired on magnetic resonance imaging was used to measure "normal-appearing" WM microstructure at baseline and 24-months. Clinical variables such as cognitive and blood-based measures were collected longitudinall..

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Awarded by Australia's National Health and Medical Research Council

Funding Acknowledgements

The authors declare that this study received funding from Australia's National Health and Medical Research Council; Contract grant number: 1005492. Funding for the AIBL study is provided by the CSIRO Flagship Collaboration Fund and the Science and Industry Endowment Fund (SIEF) in partnership with Edith Cowan University (ECU), Mental Health Research institute (MHRI), Alzheimer's Australia (AA), National Ageing Research Institute (NARI), Austin Health, Hollywood Private Hospital, Sir Charles Gardner Hospital. The study also received funding from the National Health and Medical Research Council, the Dementia Collaborative Research Centres program (DCRC2) and The McCusker Alzheimer's Research Foundation and Operational Infrastructure Support from the Government of Victoria. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication.