'Snail factors in testicular germ cell tumours and their regulation by the BMP4 signalling pathway'
Diana J Micati, Karthika Radhakrishnan, Julia C Young, Ewa Rajpert-De Meyts, Gary R Hime, Helen E Abud, Kate L Loveland
Andrology | WILEY | Published : 2020
BACKGROUND: Snail transcription factors mediate key cellular transitions in many developmental processes, including spermatogenesis, and their production can be regulated by TGF-β superfamily signalling. SNAI1 and SNAI2 support many cancers of epithelial origin. Their functional relevance and potential regulation by TGF-β superfamily ligands in germ cell neoplasia are unknown. METHODS: SNAI1, SNAI2 and importin 5 (IPO5; nuclear transporter that selectively mediates BMP signalling) cellular localisation was examined in fixed normal adult human and/or neoplastic testes using in situ hybridisation and/or immunohistochemistry. SNAI1 and SNAI2 functions were assessed using the well characterised ..View full abstract
Awarded by National Health and Medical Research Council of Australia
This work was supported by grants from the National Health and Medical Research Council of Australia (Project grant ID1048110 to GH, HA, KL and Fellowship ID1079646 to KL).