‘Snail factors in testicular germ cell tumours and their regulation by the BMP4 signalling pathway’

DJ Micati; K Radhakrishnan; JC Young; E Rajpert-De Meyts; GR Hime; HE Abud; KL Loveland

Journal article

‘Snail factors in testicular germ cell tumours and their regulation by the BMP4 signalling pathway’

DJ Micati, K Radhakrishnan, JC Young, E Rajpert-De Meyts, GR Hime, HE Abud, KL Loveland

Andrology | WILEY | Published : 2020

DOI: 10.1111/andr.12823

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Abstract

Background: Snail transcription factors mediate key cellular transitions in many developmental processes, including spermatogenesis, and their production can be regulated by TGF-β superfamily signalling. SNAI1 and SNAI2 support many cancers of epithelial origin. Their functional relevance and potential regulation by TGF-β superfamily ligands in germ cell neoplasia are unknown. Methods: SNAI1, SNAI2 and importin 5 (IPO5; nuclear transporter that selectively mediates BMP signalling) cellular localization was examined in fixed normal adult human and/or neoplastic testes using in situ hybridization and/or immunohistochemistry. SNAI1 and SNAI2 functions were assessed using the well-characterized ..

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University of Melbourne Researchers

Gary Hime Author

Related Projects (1)

Role of Snail family proteins in male fertility and testicular cancer

Male fertility requires production of healthy sperm in the testis. This project builds on our discoveries that testicular cells regulate gen..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by grants from the National Health and Medical Research Council of Australia (Project grant ID1048110 to GH, HA, KL and Fellowship ID1079646 to KL).