Journal article
PEACE V - Salvage Treatment of OligoRecurrent nodal prostate cancer Metastases (STORM): a study protocol for a randomized controlled phase II trial
A De Bruycker, A Spiessens, P Dirix, N Koutsouvelis, I Semac, N Liefhooghe, A Gomez-Iturriaga, W Everaerts, F Otte, A Papachristofilou, M Scorsetti, M Shelan, S Siva, F Ameye, M Guckenberger, R Heikkila, PM Putora, A Zapatero, A Conde-Moreno, F Counago Show all
BMC Cancer | BioMed Central | Published : 2020
Abstract
Background: Pelvic nodal recurrences are being increasingly diagnosed with the introduction of new molecular imaging techniques, like choline and PSMA PET-CT, in the restaging of recurrent prostate cancer (PCa). At this moment, there are no specific treatment recommendations for patients with limited nodal recurrences and different locoregional treatment approaches are currently being used, mostly by means of metastasis-directed therapies (MDT): salvage lymph node dissection (sLND) or stereotactic body radiotherapy (SBRT). Since the majority of patients treated with MDT relapse within 2 years in adjacent lymph node regions, with an estimated median time to progression of 12–18 months, combin..
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Funding Acknowledgements
This study is funded by a Swiss Prostate Cancer Award grant from the Movember Foundation and by a Belgian research grant from 'Kom Op Tegen Kanker' and 'Stichting tegen Kanker'. The granting bodies are not involved in study design, data collection, execution of the trial, analysis, interpretation of data, decision to submit results and writing of the report. Prof. Dr. P. Ost and Prof. Dr. W. Everaerts are both senior Clinical Investigators of the Research Foundation -Flanders (Belgium) (FWO). The corresponding authors will have full access to all data in the study and have final responsibility for the decision to submit for publication.