Journal article

Technical Note: Rapid multiexponential curve fitting algorithm for voxel-based targeted radionuclide dosimetry

Price Jackson, Lachlan McIntosh, Michael S Hofman, Grace Kong, Rodney J Hicks

Medical Physics | WILEY | Published : 2020

Abstract

BACKGROUND: Dosimetry in nuclear medicine often relies on estimating pharmacokinetics based on sparse temporal data. As analysis methods move toward image-based three-dimensional computation, it becomes important to interpolate and extrapolate these data without requiring manual intervention; that is, in a manner that is highly efficient and reproducible. Iterative least-squares solvers are poorly suited to this task because of the computational overhead and potential to optimize to local minima without applying tight constraints at the outset. METHODOLOGY: This work describes a fully analytical method for solving three-phase exponential time-activity curves based on three measured time poin..

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Grants

Awarded by National Health and Medical Research Council Practitioner Fellowship


Funding Acknowledgements

PJ is supported by a Victorian Cancer Agency clinical fellowship. Initial clinical data provided through grant support by the Victorian Cancer Agency clinical trial, "GaTate-PET/CT to predict LuTate dosimetry in patients with neuroendocrine tumour disease: a pilot study" (CI RJH). MSH is supported by a Clinical Fellowship Award from the Peter MacCallum Foundation and receives grants from the Prostate Cancer Foundation (PCF), November, U.S. Department of Defence and the Prostate Cancer Foundation of Australia. He also receives research funding from Advanced Accelerator Applications (a Novartis company). GK is supported by a Clinical Fellowship Award from the Peter MacCallum Foundation. RJH is recipient of a National Health and Medical Research Council Practitioner Fellowship (APP1108050). The authors thank David Sarrut for his advice and input in evaluating the methodology in comparison to his previously published technique.