Journal article
High placental inositol content associated with suppressed pro-adipogenic effects of maternal glycaemia in offspring: the GUSTO cohort
Anne HY Chu, Mya T Tint, Hsin F Chang, Gerard Wong, Wen Lun Yuan, Dedreia Tull, Brunda Nijagal, Vinod K Narayana, Peter J Meikle, Kenneth TE Chang, Rohan M Lewis, Claudia Chi, Fabian KP Yap, Kok Hian Tan, Lynette P Shek, Yap-Seng Chong, Peter D Gluckman, Yung Seng Lee, Marielle Fortier, Keith M Godfrey Show all
INTERNATIONAL JOURNAL OF OBESITY | SPRINGERNATURE | Published : 2021
Abstract
Background/Objectives Maternal glycaemia promotes fetal adiposity. Inositol, an insulin sensitizer, has been trialled for gestational diabetes prevention. The placenta has been implicated in how maternal hyperglycaemia generates fetal pathophysiology, but no studies have examined whether placental inositol biology is altered with maternal hyperglycaemia, nor whether such alterations impact fetal physiology. We aimed to investigate whether the effects of maternal glycaemia on offspring birthweight and adiposity at birth differed across placental inositol levels. Methods Using longitudinal data from the Growing Up in Singapore Towards healthy Outcomes cohort, maternal fasting glucose (FPG) an..
View full abstractGrants
Awarded by Singapore National Medical Research Council
Awarded by UK Medical Research Council
Awarded by National Institute for Health Research (NIHR)
Awarded by European Union (Erasmus+ Programme Early Nutrition eAcademy Southeast Asia)
Awarded by Singapore Ministry of Health's National Medical Research Council (NMRC), Singapore
Funding Acknowledgements
This research is supported by the Singapore National Research Foundation under its Translational and Clinical Research (TCR) Flagship Programme and administered by the Singapore Ministry of Health's National Medical Research Council (NMRC), Singapore -NMRC/TCR/004-NUS/2008; NMRC/TCR/012-NUHS/2014. This research is also supported by a Clinician Scientist Award to SYC from the Singapore National Medical Research Council (NMRC/CSAINV/0010/2016). KMG is supported by the UK Medical Research Council (MC_UU_12011/4), the National Institute for Health Research (NIHR Senior Investigator (NF-SI-0515-10042) and the NIHR Southampton Biomedical Research Centre) and the European Union (Erasmus+ Programme Early Nutrition eAcademy Southeast Asia-573651-EPP-1-2016-1-DE-EPPKA2-CBHE-JP). Additional funding is provided by the Singapore Institute for Clinical Sciences (SICS), Agency for Science Technology and Research (A*STAR), and Metabolomics Australia at the University of Melbourne, a member of Bioplatforms Australia Pty Ltd. funded through the National Collaborative Research Infrastructure Strategy (NCRIS).