Journal article
The effects of vitamin K-rich green leafy vegetables on bone metabolism: A 4-week randomised controlled trial in middle-aged and older individuals
Marc Sim, Joshua R Lewis, Richard L Prince, Itamar Levinger, Tara C Brennan-Speranza, Claire Palmer, Catherine P Bondonno, Nicola P Bondonno, Amanda Devine, Natalie C Ward, Elizabeth Byrnes, Carl J Schultz, Richard Woodman, Kevin Croft, Jonathan M Hodgson, Lauren C Blekkenhorst
BONE REPORTS | ELSEVIER | Published : 2020
Abstract
Background: High vegetable intake is associated with beneficial effects on bone. However, the mechanisms remain uncertain. Green leafy vegetables are a rich source of vitamin K1, which is known to have large effects on osteoblasts and osteocalcin (OC) metabolism. Objective: To examine the effects of consumption of two to three extra serves of green leafy vegetables daily on bone metabolism. Methods: Thirty individuals (mean age 61.8 ± 9.9 years, 67% male) completed three experimental phases in a randomised controlled crossover design, each lasting four weeks, with a washout period of four weeks between phases (clinical trial registration: ACTRN12615000194561). The three experimental phases w..
View full abstractGrants
Awarded by National Health and Medical Research Council of Australia
Awarded by Edith Cowan University Early Career Researcher Grant
Awarded by National Health and Medical Research Council of Australia Senior Research Fellowship
Awarded by National Heart Foundation of Australia Future Leader Fellowship
Awarded by National Health and Medical Research Council of Australia Emerging Leadership Investigator Grant
Awarded by National Heart Foundation of Australia Post-Doctoral Research Fellowship
Funding Acknowledgements
The Vegetable Intake and Blood Pressure study was supported by the National Health and Medical Research Council of Australia (1084922) and the Edith Cowan University Early Career Researcher Grant (G1004441). The salary of JMH was supported by a National Health and Medical Research Council of Australia Senior Research Fellowship (ID: 1116973). The salary of JRL is supported by a National Heart Foundation of Australia Future Leader Fellowship (ID: G1004431). The salary of LCB is supported by a National Health and Medical Research Council of Australia Emerging Leadership Investigator Grant (ID: 1172987) and a National Heart Foundation of Australia Post-Doctoral Research Fellowship (ID: 102498). None of these funding agencies had any role in the conduct of the study; collection, management, analysis or interpretation of the data; or the preparation, review or approval of the manuscript.