Journal article

The effects of vitamin K-rich green leafy vegetables on bone metabolism: A 4-week randomised controlled trial in middle-aged and older individuals

Marc Sim, Joshua R Lewis, Richard L Prince, Itamar Levinger, Tara C Brennan-Speranza, Claire Palmer, Catherine P Bondonno, Nicola P Bondonno, Amanda Devine, Natalie C Ward, Elizabeth Byrnes, Carl J Schultz, Richard Woodman, Kevin Croft, Jonathan M Hodgson, Lauren C Blekkenhorst

BONE REPORTS | ELSEVIER | Published : 2020

Abstract

Background: High vegetable intake is associated with beneficial effects on bone. However, the mechanisms remain uncertain. Green leafy vegetables are a rich source of vitamin K1, which is known to have large effects on osteoblasts and osteocalcin (OC) metabolism. Objective: To examine the effects of consumption of two to three extra serves of green leafy vegetables daily on bone metabolism. Methods: Thirty individuals (mean age 61.8 ± 9.9 years, 67% male) completed three experimental phases in a randomised controlled crossover design, each lasting four weeks, with a washout period of four weeks between phases (clinical trial registration: ACTRN12615000194561). The three experimental phases w..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Edith Cowan University Early Career Researcher Grant


Awarded by National Health and Medical Research Council of Australia Senior Research Fellowship


Awarded by National Heart Foundation of Australia Future Leader Fellowship


Awarded by National Health and Medical Research Council of Australia Emerging Leadership Investigator Grant


Awarded by National Heart Foundation of Australia Post-Doctoral Research Fellowship


Funding Acknowledgements

The Vegetable Intake and Blood Pressure study was supported by the National Health and Medical Research Council of Australia (1084922) and the Edith Cowan University Early Career Researcher Grant (G1004441). The salary of JMH was supported by a National Health and Medical Research Council of Australia Senior Research Fellowship (ID: 1116973). The salary of JRL is supported by a National Heart Foundation of Australia Future Leader Fellowship (ID: G1004431). The salary of LCB is supported by a National Health and Medical Research Council of Australia Emerging Leadership Investigator Grant (ID: 1172987) and a National Heart Foundation of Australia Post-Doctoral Research Fellowship (ID: 102498). None of these funding agencies had any role in the conduct of the study; collection, management, analysis or interpretation of the data; or the preparation, review or approval of the manuscript.