How the enriched get richer? Experience-dependent modulation of microRNAs and the therapeutic effects of environmental enrichment
Maria Kuznetsova, Carey Wilson, Anthony J Hannan, Thibault Renoir
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2020
Environmental enrichment and physical exercise have many well-established health benefits. Although these environmental manipulations are known to delay symptom onset and progression in a variety of neurological and psychiatric conditions, the mechanisms underlying these effects remain poorly understood. A notable candidate molecular mechanism is that of microRNA, a family of small noncoding RNAs that are important regulators of gene expression. Research investigating the many diverse roles of microRNAs has greatly expanded over the past decade, with several promising preclinical and clinical studies highlighting the role of dysregulated microRNA expression (in the brain, blood and other per..View full abstract
This work was supported by an ARC Discovery Early Career Research Award (TR). AJH is an NHMRC Principal Research Fellow. The Florey Institute of Neuroscience and Mental Health acknowledges the support from the Victorian Government's Operational Infrastructure Support Grant.