Journal article

Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection

Mihai G Netea, Evangelos J Giamarellos-Bourboulis, Jorge Dominguez-Andres, Nigel Curtis, Reinout van Crevel, Frank L van de Veerdonk, Marc Bonten

Cell | CELL PRESS | Published : 2020

Abstract

SARS-CoV-2 infection is mild in the majority of individuals but progresses into severe pneumonia in a small proportion of patients. The increased susceptibility to severe disease in the elderly and individuals with co-morbidities argues for an initial defect in anti-viral host defense mechanisms. Long-term boosting of innate immune responses, also termed "trained immunity," by certain live vaccines (BCG, oral polio vaccine, measles) induces heterologous protection against infections through epigenetic, transcriptional, and functional reprogramming of innate immune cells. We propose that induction of trained immunity by whole-microorganism vaccines may represent an important tool for reducing..

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Awarded by ERC


Awarded by National Institutes of Health


Awarded by European Union


Funding Acknowledgements

M.G.N. was supported by an ERC advanced grant (833247) and a Spinoza grant of the Netherlands Association for Scientific Research. R.v.C. is supported by the National Institutes of Health (R01AI145781) and European Union (RIA2018CO-2514-PROTID).