Journal article

A single dose of quadrivalent human papillomavirus (HPV) vaccine is immunogenic and reduces HPV detection rates in young women in Mongolia, six years after vaccination

Tsetsegsaihan Batmunkh, Marguerite T Dalmau, Margad-Erdene Munkhsaikhan, Tungalagtuya Khorolsuren, Narantuya Namjil, Unursaikhan Surenjav, Zheng Quan Toh, Paul V Licciardi, Fiona M Russell, Suzanne M Garland, Kim Mulholland, Claire von Mollendorf

Vaccine | ELSEVIER SCI LTD | Published : 2020

Abstract

BACKGROUND: Emerging observational evidence suggests a single-dose of human papillomavirus (HPV) vaccine may be protective against vaccine-targeted HPV infection and associated cervical dysplasia. We aimed to demonstrate whether a single dose of quadrivalent HPV (4vHPV) vaccine was immunogenic and reduced HPV detection rates in young women in Mongolia. We also assessed knowledge and attitudes regarding HPV and the HPV vaccine. METHODS: A retrospective paired cohort study was undertaken to evaluate the effect of a single dose of 4vHPV, given at age 11-17 years in 2012, on HPV detection rates, when compared with unvaccinated women. Real time PCR was performed on self-administered vaginal swabs..

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Grants

Awarded by Bill & Melinda Gates Foundation


Funding Acknowledgements

This study was funded by the Bill & Melinda Gates Foundation (OPP118417). The study sponsor was not involved in any stage of the study design, data collection, analysis or publication process. The corresponding author confirms that she had full access to all study data and had final responsibility for the decision to submit for publication.