Functional properties and sequence variation of HTLV-1 p13
Maria Omsland, Micol Silic-Benussi, Ramona Moles, Sarkis Sarkis, Damian FJ Purcell, David Yurick, Georges Khoury, Donna M D'Agostino, Vincenzo Ciminale, Genoveffa Franchini
Retrovirology | BMC | Published : 2020
Human T cell leukemia virus type-1 (HTLV-1) was the first retrovirus found to cause cancer in humans, but the mechanisms that drive the development of leukemia and other diseases associated with HTLV-1 infection remain to be fully understood. This review describes the functional properties of p13, an 87-amino acid protein coded by HTLV-1 open reading frame II (orf-II). p13 is mainly localized in the inner membrane of the mitochondria, where it induces potassium (K+) influx and reactive oxygen species (ROS) production, which can trigger either proliferation or apoptosis, depending on the ROS setpoint of the cell. Recent evidence indicates that p13 may influence the cell's innate immune respon..View full abstract
Awarded by Italian Association for Cancer Research (AIRC) IG
Awarded by National Health and Medical Research Council of Australia
This work was supported by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research, and federal funds from the National Cancer Institute, National Institutes of Health, a grant from the Italian Association for Cancer Research (AIRC) IG #17794 to VC, institutional funds from the University of Padua (to VC and DMD), and the National Health and Medical Research Council of Australia (APP1129320 and APP1052979 to DFJP).