A Metabolic Roadmap for Somatic Stem Cell Fate
C Hai Ly, Gordon S Lynch, James G Ryall
Cell Metabolism | CELL PRESS | Published : 2020
While metabolism was initially thought to play a passive role in cell biology by generating ATP to meet bioenergetic demands, recent studies have identified critical roles for metabolism in the generation of new biomass and provision of obligate substrates for the epigenetic modification of histones and DNA. This review details how metabolites generated through glycolysis and the tricarboxylic acid cycle are utilized by somatic stem cells to support cell proliferation and lineage commitment. Importantly, we also discuss the evolving hypothesis that histones can act as an energy reservoir during times of energy stress. Finally, we discuss how cells integrate both extrinsic metabolic cues and ..View full abstract
Awarded by Australian Research Council
Awarded by National Health and Medical Research Council
This work was supported by the Australian Research Council (DP150100206) and the National Health and Medical Research Council (GNT1120714). Figures were created with Biorender.