Journal article

Global Coagulation Assays in Transgender Women on Oral and Transdermal Estradiol Therapy

Hui Yin Lim, Shalem Y Leemaqz, Niloufar Torkamani, Mathis Grossmann, Jeffrey D Zajac, Harshal Nandurkar, Prahlad Ho, Ada S Cheung

The Journal of Clinical Endocrinology & Metabolism | ENDOCRINE SOC | Published : 2020

Abstract

CONTEXT: The thrombotic effects of estradiol therapy in transgender women are unclear. Global coagulation assays (GCA) may be better measures of hemostatic function compared with standard coagulation tests. OBJECTIVE: To assess the GCA profiles of transgender women in comparison to cisgender controls and to compare how GCA differ between routes of estradiol therapy in transgender women. DESIGN: Cross-sectional case-control study. SETTING: General community. PARTICIPANTS: Transgender women, cisgender male and cisgender female controls. MAIN OUTCOME MEASURES: Citrated blood samples were analyzed for (i) whole blood thromboelastography (TEG®5000), (ii) platelet-poor plasma thrombin generation (..

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Grants

Awarded by Heart Foundation Health Professional Scholarship


Awarded by Australian Government National Health and Medical Research Council Early Career Fellowship


Funding Acknowledgements

Dr Hui Yin Lim is a recipient of the co-funded National Health and Medical Research Council Postgraduate Scholarship and Heart Foundation Health Professional Scholarship (#1151535). Ada Cheung is supported by an Australian Government National Health and Medical Research Council Early Career Fellowship (#1143333) and receives research support from the Viertel Charitable Foundation Clinical Investigator Award, Endocrine Society of Australia Postdoctoral Award and the Royal Australasian College of Physicians Vincent Fairfax Family Foundation.