Changes in pancreatic exocrine function in young at-risk children followed to islet autoimmunity and type 1 diabetes in the ENDIA study
Megan AS Penno, Helena Oakey, Priya Augustine, Mario Taranto, Simon C Barry, Peter G Colman, Maria E Craig, Elizabeth A Davis, Lynne C Giles, Mark Harris, Aveni Haynes, Kelly McGorm, Grant Morahan, Claire Morbey, William D Rawlinson, Richard O Sinnott, Georgia Soldatos, Rebecca L Thomson, Peter J Vuillermin, John M Wentworth Show all
PEDIATRIC DIABETES | WILEY | Published : 2020
BACKGROUNDS: We aimed to monitor pancreatic exocrine function longitudinally in relation to the development of islet autoimmunity (IA) and type 1 diabetes (T1D) in at-risk children with a first-degree relative with T1D, who were followed prospectively in the Environmental Determinants of Islet Autoimmunity (ENDIA) study. METHODS: Fecal elastase-1 (FE-1) concentration was measured longitudinally in 85 ENDIA children from median age 1.0 (IQR 0.7,1.3) year. Twenty-eight of 85 children (progressors) developed persistent islet autoantibodies at median age of 1.5 (IQR 1.1,2.5) years, of whom 11 went on to develop clinical diabetes. The other 57 islet autoantibody-negative children (non-progressors..View full abstract
This research is supported by JDRF Australia, the recipient of the Australian Research Council Special Research Initiative in Type 1 Juvenile Diabetes, The Leona M. and Harry B. Helmsley Charitable Trust, and JDRF International; in addition to The National Health and Medical Research Council of Australia.