Circulating mRNAs are differentially expressed in pregnancies with severe placental insufficiency and at high risk of stillbirth

Natalie J Hannan; Owen Stock; Rebecca Spencer; Clare Whitehead; Anna L David; Katie Groom; Scott Petersen; Amanda Henry; Joanne M Said; Sean Seeho; Stefan C Kane; Lavinia Gordon; Sally Beard; Kantaraja Chindera; Smita Karegodar; Richard Hiscock; Natasha Pritchard; Tu'uhevaha J Kaitu'u-Lino; Susan P Walker; Stephen Tong

Journal article

Circulating mRNAs are differentially expressed in pregnancies with severe placental insufficiency and at high risk of stillbirth

Natalie J Hannan, Owen Stock, Rebecca Spencer, Clare Whitehead, Anna L David, Katie Groom, Scott Petersen, Amanda Henry, Joanne M Said, Sean Seeho, Stefan C Kane, Lavinia Gordon, Sally Beard, Kantaraja Chindera, Smita Karegodar, Richard Hiscock, Natasha Pritchard, Tu'uhevaha J Kaitu'u-Lino, Susan P Walker, Stephen Tong

BMC Medicine | BMC | Published : 2020

DOI: 10.1186/s12916-020-01605-x

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Abstract

BACKGROUND: Fetuses affected by placental insufficiency do not receive adequate nutrients and oxygenation, become growth restricted and acidemic, and can demise. Preterm fetal growth restriction is a severe form of placental insufficiency with a high risk of stillbirth. We set out to identify maternal circulating mRNA transcripts that are differentially expressed in preterm pregnancies complicated by very severe placental insufficiency, in utero fetal acidemia, and are at very high risk of stillbirth. METHODS: We performed a cohort study across six hospitals in Australia and New Zealand, prospectively collecting blood from 128 pregnancies complicated by preterm fetal growth restriction (deli..

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University of Melbourne Researchers

Tu'uhevaha Lino Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

Stefan Kane Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

Steven Tong Author Infectious Diseases

Susan Walker Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

Stephen Tong Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

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Grants

Awarded by National Health and Medical Research Council

Awarded by European Union

Funding Acknowledgements

This research was supported by The National Health and Medical Research Council (Project grant #1028521, Synergy Grant #1183854, salary support to OS #1055795, NJH #1146128, KL #1159261 and ST #11364118) and the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 305823. ALD receives salary support from the UK National Institute for Health Research University College London Hospitals Biomedical Research Centre.